The susceptibility of guided bone regeneration (GBR) material to infection by pathogens\nat wound sites during bone healing has often been overlooked. The objective of this study was the\nsynthesis and characterization of a potential material for antibacterial GBR application. In the current\nstudy, the mechanical strength and biocompatibility of a composite restoration materialââ?¬â?made\nof oxidized hyaluronic acid (HA)/type I collagen hydrogel integrated with tricalcium phosphate\n(Ã?²-TCP) using a natural crosslinking agent, oligomeric proanthocyanidins (OPCs)ââ?¬â?were evaluated.\nThe suitability of the material as a carrier matrix for antibacterial applications was evaluated by\nfollowing the drug-release profile of tetracycline loaded within the composite. Results indicated that\nthis composite material had a high swelling ratio of 420% and mechanical strength of 25 kPa while\nremaining at more than 60% of the weight after 30 days of an in vitro degradation test with good\nbiocompatibility in promoting the proliferation of MG-63 cells. Drug release studies further showed\nthat 93% of the tetracycline was released after 5 days, which supports this GBR materialââ?¬â?¢s capability\nto release antibacterial drugs while keeping other required GBR material design functions.
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